Reports an interim analysis of the relationship between undetectable viral load and HIV transmission in the Opposites Attract observational cohort study of homosexual male serodiscordant couples in Australia. Finds no linked HIV transmissions in 150 ‘couple years of follow up’ among homosexual male serodiscordant couples, despite close to six thousand acts of condomless anal sex.
Analyses 14 studies to find evidence about the effects of STI co-infection on transmission from individuals on ART is very limited. Available data suggests the average effect of STI co-infection on HIV viral load in individuals on ART is unlikely to decrease the effectiveness of treatment as prevention. However, limited data precluded ruling out the possibility that particular STIs pose a larger threat.
Meta-analysis suggests minimal risk of sexual HIV transmission for heterosexual serodiscordant couples when the HIV-positive partner has full viral suppression on cART with caveats regarding information on sexual intercourse type, STIs, and condom use.
Systemic review and meta-analysis of 50 studies considered HIV transmission risk between heterosexual partners. Found ART substantially reduces HIV infection risk within serodiscordant couples.
Reports findings of OPTN 052 study based in nine countries, which found early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy.
Describes findings of the HPTN 052 study: that early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy.
Review of existing studies to show that a person with HIV who has no other sexually transmissible infection, has adhered to antiretroviral therapy (ART) for at least 6 months to achieve completely suppressed viremia, and is monitored by an attending physician cannot pass on the virus through sexual contact.
Outlines the background to the Swiss Statement, reactions to the Swiss Statement, and the fact that subsequent research has not undermined its assertions. Includes observations about its legacy, including more honest communication between patients and clinicians, and the development of official guidelines recognising the effectiveness of ART.
Review and meta-analysis of 11 articles found no HIV transmission among heterosexual discordant couples when the positive patient was treated with ART and had a viral load below 400 copies (with data compatible with one transmission per 79 years).
Considers the reliability of viral load as a condition preventing HIV transmission. Found reliability is high with compliance taking medication the most important factor predicting reliability.
Review of 14 rigorous studies to re-estimate condom effectiveness in reducing heterosexual transmission of HIV. Finds consistent condoms use results in an 80% reduction in HIV incidence, i.e 80% less than the particular act without condoms. Consistent use is defined as using a condom for all acts of penetrative vaginal intercourse.