This issue brief shares lessons and reflections on enabling legal environments, including decriminalisation, to inform the implementation of key commitments in the 2021 Political Declaration on HIV and AIDS and the Global AIDS Strategy. These include a shared understanding of the harms caused by the overly broad and unjust application of criminal laws; sensitization of key stakeholders and their engagement in legal review processes; A well-informed judiciary; Coordinated, multi-pronged and multisectoral legal advocacy; and, global and regional advocacy to advance national-level changes to HIV-related punitive and discriminatory laws, including decriminalization.